Currently Published Papers in Herbal Chemistry

Evaluation of Skeletal Muscle Relaxant Activity of Ethanolic Extract of Lantana Camara Linn.

Lincy Joseph, Mathew George, Anmol Sharma, Naina Sara Sabu

The objective of present study was to evaluate the effect of the ethanolic extracts of lantana camara leaves in experimental animals for skeletal muscle relaxant activity. Ethanolic extract of lanata camara linn. Subjected to preliminary qualitative phtyochemical investigation and acute oral toxicity study for the test extract of the plant was carried out using OECD guidelines.  The skeletal muscle relaxant activity of the ethanolic extract of the drug (60mg/kg) was evaluated in rats using rota-rod apparatus. The diazepam was taken as the standard drug and results obtained after Ethanolic extract of lanata camara linn administration was compared with the standard drug and results obtained were significant up to 2 hr study as P‹ 0.01. The result suggest that the Ethanolic extract of lanata camara linn of herbal o

Effect of curcuma aromatica on nicotine induced Hormonal changes in female albino rats

N.Poonkodi and V. Elango

Tobacco use has reached the proportion of a global epidemic .Studies show that there is an association between nicotine of cigarette smoke and serum levels of sex hormones. This investigation was done to determine the nicotine induced toxicity (subcutaneously injected at the dosage of4mg/kg b.wt. per day for 30 days) on different tissues of female albino rats and corresponding ameliorative observations of Curcuma aromatica (orally administered at dose of 100 mg per kg b.wt. per day during the treatment). Nicotine causes significant changes in the organ weight (ovary and uterus) and affects the production of female hormones more significantly. Curcuma aromatica effectively ameliorates the deleterious effect of nicotine.">

Phytochemical Screening and Physiologic Functions of Metals in Seed and Peel of Citrullus lanatus (Watermelon)

EDORI, Onisogen Simeon and MARCUS, Abiye Clement

The seed and peel of Citrullus lanatus (watermelon), a very commonly consumed fruit were examined for metals and phytochemicals. The metals were examined with atomic absorption spectrophotometer while the phytochemicals were determined through standard methods of phytochemical analysis after extraction of the Citrullus lanatus with ethyl acetate and water. The results of metal analysis showed that iron (Fe) was highest in concentration in both seed (29.73 mg/Kg) and peel (32. 60 mg/Kg) of the Citrullus lanatus, followed by manganese (Mn) in the seed (11.67 mg/Kg) and peel (14. 14 mg/Kg); zinc (Zn) in seed was 7.89 mg/Kg and peel was 9.11 mg/Kg and magnesium (Mg) in seed was 1.47 mg/Kg and peel was 1.28 mg/Kg of the Citrullus lanatus. However, other metal ions detected (calcium (Ca), copper, (Cu), potassium (K), nickel (Ni) and Lead (Pb) were lower than 1.0 mg/Kg in the seed or peel of the Citrullus lanatus. Arsenic (Ar) and selenium (Se) were undetected in both seed and peel of the Citrullus lanatus. Phytochemical screening of the ethyl acetate extracts of seed and peel of the Citrullus lanatus revealed the presence of flavonoids, terpenoids and cardiac glycosides in both seed and peel of watermelon. Tannins was only present in the seed, while phenols, carboxylic acid, quinone and xanthoproteins were absent in the seed. All the components examined were present in the peel except tannins. Phytochemical examination of the aqueous extract of the seed and peel of the watermelon showed that only carboxylic acid was present in the seed, while in the peel, flavonoids, terpenoids, cardiac glycosides, carboxylic acid and xanthoproteins were present. The result of the analysis indicated that these supposed wastes (seed and peel) of the Citrullus lanatus contain vital chemical components that can serve useful purposes in health, food and feeds supplements.

Flavanols LC/MS and 1H-RMN from Ivorian Cassia sieberiana

Lancine Traore, Yves-Alain Bekro, Pascale Guiffrey, Jean-Luc Pirat, David Virieux, Emmanuelle Meudec, Janat A. Mamyrbekova-Bekro

Cassia sieberiana is a plant used in Africa and particularly in Côte d'Ivoire for its therapeutic properties. Phytochemical screening of this plant’s root bark put in evidence the presence of polyphenols, flavonoids, coumarins, tannins, saponins, sterols and terpenes. The present study focused on the characterization and structural elucidation by LC/MS and 1H-NMR of afzelechin and epiafzelechin, two flavonoid epimers isolated by flash chromatography from the aglycone’s fraction gotten of ethyl acetate extract of the root bark from Cassia sieberiana rich in total flavonoid aglycones.

Squalene and ß-sitosterol from Afraegle paniculata unsaponifiable

Souleymane Bamba, Janat Akhanovna Mamyrbekova-Bekro, David Virieux, Pascale Guiffrey, Jean-Luc Pirat, Yves-Alain Bekro

Squalene and ß-sitosterol have been isolated for the first time from Afraegle paniculata unsaponifiable fraction, a Rutaceae of Côte d’Ivoire. Their respective molecular structure has been determined by spectrometric methods, including GC/MS, IR, 1H- and 13C- NMR.