Currently Published Papers in Herbal Chemistry

Nutritional Value of Ocimum Sanctum

Sudeshna Biswas, Sufia Zaman and Abhijit Mitra; IJGHC, March 2018 – May 2018; Sec. B; Vol.7, No.2, 200-203.; DOI: 10.24214/IJGHC/HC/7/2/20003.

The leaves of Ocimum sanctum were analysed for its proximate and mineral composition. Fresh leaves of tulsi were collected from Sonamukhi region (23°18'27.27"N and 87°24'56.86"E) of Bankura district in West Bengal from different patches. The proximate and mineral composition of the leaves of O. sanctum was analyzed using standard methods of food analysis. The results show high carbohydrate content in the leaves with considerable protein content and low percentage of fat. Mineral composition indicated that the leaves of the species are good sources of K, Ca and Mg. High K content in the leaves suggest the plant to be highly beneficial for patients having blood pressure and hypertension.

Antibacterial activity of Withania somnifera leaf extracts against gram-positive and gram-negative bacteria.

Dr. Mayuri Thanwar, Dr. Dhananjay Dwivedi, Dr.Anil Kumar Gharia; IJGHC, March 2018 – May 2018; Sec. B; Vol.7, No.2, 194-199.; DOI: 10.24214/IJGHC/HC/7/2/19499.

Withania somnifera is an important medicinal plant used in ayurvedic system of medicine since ancient times. The plant have potential to treat arthritis and rheumatism diseases so attention has been drawn to study antibacterial activity of the plant to challenge on antibacterial resistant pathogens. Four solvent extracts from leaves of withania somnifera tested against four test human pathogens viz., Staphylococcus aureus, Bacillus subtilis, Escherichia coli.

Synthesis of Acridine Derivatives Using Ionic Liquid as Promoter

V. G.Kalalawe, D. R.Munde, R. P.Kagne, S.N.Niwadange, R. D.Gutte; IJGHC, March 2018 – May 2018; Sec. B; Vol.7, No.2, 188-193.; DOI: 10.24214/IJGHC/HC/7/2/18893.

A facile and convenient protocol for the synthesis of high yielding acridine derivatives has been developed by one-pot three component reaction of dimedone, aromatic aldehyde and ammonium acetate using ionic liquid.

In vitro anti-inflammatory and anti-hypertensive activity of Erinocarpusnimmonii methanol leaf extract

Anitha Puranik, Anantacharya R and Parimala R.; IJGHC, March 2018 – May 2018; Sec. B; Vol.7, No.2, 180-187.; DOI: 10.24214/IJGHC/HC/7/2/18087.

Anti-inflammatory and antihypertensive potency of Erinocarpusnimmonii Grath a rare endangered and threatened species (RET) was investigated. Leaf extract was prepared by using methanol as solvent; extraction was carried out by cold method. The anti-inflammatory analysis was carried out with the help of hyaluronidase inhibition assay and antihypertensive activity was by using colorimetric, high-throughput assay, Indomethacin and Captopril is used as reference standards in assays respectively. The extract exhibited anti-inflammatory and antihypertensive potentialities in a concentration dependent manner. The methanol crude extract exhibited inhibition of 43.42 % of hyaluronidase enzyme and inhibition of 11.46 % of acetyl choline esterase enzyme at 100 μg. The crude extracts needs further detailed study towards mechanism of action, drug discovery and drug design.

Bioactive Polyphenols and Coumarins from Leaf Derived Callus and in vitro Regenerated Plants of Taraxacum officinale Weber

Neha Sahu, Awantika Singh, Brijesh Kumar, K.R. Arya; IJGHC, March 2018 – May 2018; Sec. B; Vol.7, No.2, 166-179.; DOI: 10.24214/IJGHC/HC/7/2/16679.

Taraxacum officinale is a well-known Indian traditional plant used to treat several kinds of ailments. Evolving industrial importance of herbal products in recent past, created a high demand of naturally occurring phytochemicals and their biosynthesis using plant tissue culture technology. Polyphenol and coumarin class of compounds are well known phytochemicals for several pharmaceutical applications including chemoprevention. In this paper we report a fast and renewable method for in vitro biosynthesis of quinic acid, protocatechuic acid, chlorogenic acid and umbelliferone from leaf derived in vitro cultures of Taraxacum officinale. MS media supplemented with 0.25 mg/L 2, 4-D with 0.05 mg/L KIN and 0.25 mg/L 2, 4-D with 0.05 mg/L 2iP prove to be the best hormonal combination for optimal growth and proliferation of callus and 2.5 mg/L NAA with 0.5 mg/L BAP for direct shoot organogenesis from leaf explant of T. officinale. Quantitative determination through UHPLC-MS/MS analysis attributes the novelty for identification and enhance accumulation of quinic acid by 21.24 and 18.47, protocatechuic acid 0.98 and 1.77, chlorogenic acid 3.49 and 2.12 and umbelliferone by 4.69 and 2.54 folds in callus and in vitro regenerated plantlets respectively as compared to wild. Remarkably, the quinic acid was found to increase by 38.57 folds in acclimatized plants as compared to wild.">